| Meredith Grey (Ellen Pompeo) | 12 Temporadas |
| Richard Webber (James Pickens Jr.) | |
| Miranda Bailey (Chandra Wilson) | |
| Alex Karev (Justin Chambers) | |
| Derek Shepherd (Patrick Dempsey) | 11 Temporadas |
| Callie Torres (Sara Ramírez) | |
| Cristina Yang (Sandra Oh) | 10 Temporadas |
| Arizona Robbins (Jessica Capshaw) | 8 Temporadas |
| Mark Sloan (Eric Dane) | |
| Owen Hunt (Kevin McKidd) | 7 Temporadas |
| Jackson Avery (Jesse Williams) | |
| April Kepner (Sarah Drew) | |
| Ben Warren (Jason Winston George) | |
| Izzie Stevens (Katherine Heigl) | 6 Temporadas |
| George O'Malley (T.R. Knight) | |
| Lexie Grey (Chyler Leigh) |
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